Chemical Name: 3-[8-Amino-1-(2-phenyl-7-quinolyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol. Alternate Names: OSI-906
IGF-1R kinase / InsR kinase inhibitor
Molekulargewicht:
421.49
Reinheit:
98% by HPLC NMR (Conforms)
Formulierung:
Yellow solid
CAS Nummer:
[867160-71-2]
Formel:
C26H23N5O
Anwendungsbeschreibung:
Linsitinib is a potent and selective dual inhibitor of insulin-like growth factor 1 (IGF-1R) kinase and insulin receptor (InsR) kinase (IC50s = 35 and 75 nM respectively).1 It has been investigated as a chemotherapeutic in combination with other drugs for various cancers.2-6
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