Defactinib, CAS [[1073154-85-4]]

Produktübersicht

• Artikelname: Defactinib, CAS [[1073154-85-4]]
• Artikelnummer: FBM-10-4828
• Hersteller Artikelnummer: 10-4828
• Alternativnummer: FBM-10-4828-5MG, FBM-10-4828-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-Methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]aminl]benzamide. Alternate Names: PF-04554878, VS-6063

Produktbeschreibung

FAK inhibitor

Produkteigenschaften

• Molekulargewicht: 510.50
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1073154-85-4]
• Formel: C20H21F3N8O3S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Defactinib (1073154-85-4) is a potent inhibitor of FAK (IC50 = 0.6nM) and Pyk2 (IC50 = 0.6nM).1 It is active in vivo (EC50 = 26nM). FAK inhibition prevents tumor invasion and dissemination rather than tumor size reduction. Defactinib has been shown to preferentially target cancer stem cells in a mouse xenograft model of triple negative breast cancer.2 It is in multiple clinical trials for various cancers3 and in shows synergistic activity when used in combination with checkpoint immunotherapy 4-6.