Defactinib, CAS [[1073154-85-4]]

Product Overview

• Article Name: Defactinib, CAS [[1073154-85-4]]
• Biozol Catalog Number: FBM-10-4828
• Supplier Catalog Number: 10-4828
• Alternative Catalog Number: FBM-10-4828-5MG,FBM-10-4828-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: PF-04554878, VS-6063

Product Description

FAK inhibitor

Product Properties

• Molecular Weight: 510.50
• Purity: 98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1073154-85-4]
• Formula: C20H21F3N8O3S

Application Notes

• Application Notes: Defactinib (1073154-85-4) is a potent inhibitor of FAK (IC50 = 0.6nM) and Pyk2 (IC50 = 0.6nM).1 It is active in vivo (EC50 = 26nM). FAK inhibition prevents tumor invasion and dissemination rather than tumor size reduction. Defactinib has been shown to preferentially target cancer stem cells in a mouse xenograft model of triple negative breast cancer.2 It is in multiple clinical trials for various cancers3 and in shows synergistic activity when used in combination with checkpoint immunotherapy 4-6.