FB23-2, CAS [[2243736-45-8]]

Produktübersicht

• Artikelname: FB23-2, CAS [[2243736-45-8]]
• Artikelnummer: FBM-10-4852
• Hersteller Artikelnummer: 10-4852
• Alternativnummer: FBM-10-4852-5MG, FBM-10-4852-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-[2,6-Dichloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)anilino]-N-hydroxybenzamide

Produktbeschreibung

FTO inhibitor

Produkteigenschaften

• Molekulargewicht: 392.24
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [2243736-45-8]
• Formel: C18H15Cl2N3O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: FB23-2 is an inhibitor (IC50 = 2.6 µM) of the mRNA m6A demethylase fat-mass- and obesity-associated protein (FTO).1 Displays significant anti-proliferative activity in NB4 (IC50 = 0.8 µM) and MONOMAC6 (IC50 = 1.5 µM) cells. Selective against the RNA demethylase ALKB5. FB23-2 induced myeloid differentiation and apoptosis in acute myeloid leukemia cells. FB23-2 suppressed the proliferation and migration of hepatocellular carcinoma cells via suppressing the expression of the kinase ERBB3 and human tubulin beta class Iva (TUBB4A).2