FB23-2, CAS [[2243736-45-8]]

Product Overview

• Article Name: FB23-2, CAS [[2243736-45-8]]
• Biozol Catalog Number: FBM-10-4852
• Supplier Catalog Number: 10-4852
• Alternative Catalog Number: FBM-10-4852-5MG, FBM-10-4852-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-[2,6-Dichloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)anilino]-N-hydroxybenzamide

Product Description

FTO inhibitor

Product Properties

• Molecular Weight: 392.24
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [2243736-45-8]
• Formula: C18H15Cl2N3O3

Application Notes

• Application Notes: FB23-2 is an inhibitor (IC50 = 2.6 µM) of the mRNA m6A demethylase fat-mass- and obesity-associated protein (FTO).1 Displays significant anti-proliferative activity in NB4 (IC50 = 0.8 µM) and MONOMAC6 (IC50 = 1.5 µM) cells. Selective against the RNA demethylase ALKB5. FB23-2 induced myeloid differentiation and apoptosis in acute myeloid leukemia cells. FB23-2 suppressed the proliferation and migration of hepatocellular carcinoma cells via suppressing the expression of the kinase ERBB3 and human tubulin beta class Iva (TUBB4A).2