UH15-382HCl, CAS [[2540881-21-6]]

Produktübersicht

• Artikelname: UH15-382HCl, CAS [[2540881-21-6]]
• Artikelnummer: FBM-10-4862
• Hersteller Artikelnummer: 10-4862
• Alternativnummer: FBM-10-4862-5MG, FBM-10-4862-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-(3-Hydroxyphenyl)-1-methyl-7-[3-(4-methylpiperazin-1-yl)anilino]-1,6-naphthyridin-2-one dihydrochloride

Produktbeschreibung

RIP3K inhibitor

Produkteigenschaften

• Molekulargewicht: 514.45
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [2540881-21-6]
• Formel: C26H27N5O22HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: UH15-38 is a potent (IC50 = 20 nM) inhibitor of RIPK3 with excellent cellular activity. It blocked TNF-induced necroptosis in primary mouse embryonic fibroblasts (IC50 = 98 nM). UH15-38 selectively blocked influenza A-induced necroptosis over apoptosis in mouse alveolar epithelial cells, mouse embryonic fibroblasts, and human M29 cells at nanomolar levels. It attenuated influenza A-induced lung injury and lethality in vivo.