UH15-382HCl, CAS [[2540881-21-6]]

Product Overview

• Article Name: UH15-382HCl, CAS [[2540881-21-6]]
• Biozol Catalog Number: FBM-10-4862
• Supplier Catalog Number: 10-4862
• Alternative Catalog Number: FBM-10-4862-5MG, FBM-10-4862-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-(3-Hydroxyphenyl)-1-methyl-7-[3-(4-methylpiperazin-1-yl)anilino]-1,6-naphthyridin-2-one dihydrochloride

Product Description

RIP3K inhibitor

Product Properties

• Molecular Weight: 514.45
• Purity: >98% by HPLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [2540881-21-6]
• Formula: C26H27N5O22HCl

Application Notes

• Application Notes: UH15-38 is a potent (IC50 = 20 nM) inhibitor of RIPK3 with excellent cellular activity. It blocked TNF-induced necroptosis in primary mouse embryonic fibroblasts (IC50 = 98 nM). UH15-38 selectively blocked influenza A-induced necroptosis over apoptosis in mouse alveolar epithelial cells, mouse embryonic fibroblasts, and human M29 cells at nanomolar levels. It attenuated influenza A-induced lung injury and lethality in vivo.