NR2E3 agonist 11a, CAS [[911211-69-3]]

Produktübersicht

• Artikelname: NR2E3 agonist 11a, CAS [[911211-69-3]]
• Artikelnummer: FBM-10-4866
• Hersteller Artikelnummer: 10-4866
• Alternativnummer: FBM-10-4866-5MG, FBM-10-4866-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-Chloro-N-[4-[6-(cyclopropanecarbonylamino)-1H-benzimidazol-2-yl]phenyl]benzamide

Produktbeschreibung

NR2E3 agonist

Produkteigenschaften

• Molekulargewicht: 430.89
• Reinheit: >98% by TLC NMR (Conforms)
• Formulierung: Pale yellow solid
• CAS Nummer: [911211-69-3]
• Formel: C24H19ClN4O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: 11a is an agonist of the photoreceptor-specific nuclear receptor (NR2E3, PNR, RNR), found in rod photoreceptor cells (EC50 = 141 nM ß-lactamase assay, 35 nM NCOR assay).1 An interesting tool for targeting age-related macular degeneration. 11a was able to increase p53 activation in uterine cancer tumors suggesting NR2E3 agonism as a new anti-cancer strategy.2 A previous study found that cytotoxicity of 11a was due to G1/S phase cell cycle arrest rather than NR2E3 agonism.3