NR2E3 agonist 11a, CAS [[911211-69-3]]

Product Overview

• Article Name: NR2E3 agonist 11a, CAS [[911211-69-3]]
• Biozol Catalog Number: FBM-10-4866
• Supplier Catalog Number: 10-4866
• Alternative Catalog Number: FBM-10-4866-5MG,FBM-10-4866-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

NR2E3 agonist

Product Properties

• Molecular Weight: 430.89
• Purity: >98% by TLC NMR (Conforms)
• Form: Pale yellow solid
• CAS Number: [911211-69-3]
• Formula: C24H19ClN4O2

Application Notes

• Application Notes: 11a is an agonist of the photoreceptor-specific nuclear receptor (NR2E3, PNR, RNR), found in rod photoreceptor cells (EC50 = 141 nM ß-lactamase assay, 35 nM NCOR assay).1 An interesting tool for targeting age-related macular degeneration. 11a was able to increase p53 activation in uterine cancer tumors suggesting NR2E3 agonism as a new anti-cancer strategy.2 A previous study found that cytotoxicity of 11a was due to G1/S phase cell cycle arrest rather than NR2E3 agonism.3