Chemical Name: 2-Chloro-N-[4-[6-(cyclopropanecarbonylamino)-1H-benzimidazol-2-yl]phenyl]benzamide
NR2E3 agonist
Molecular Weight:
430.89
Purity:
>98% by TLC NMR (Conforms)
Form:
Pale yellow solid
CAS Number:
[911211-69-3]
Formula:
C24H19ClN4O2
Application Notes:
11a is an agonist of the photoreceptor-specific nuclear receptor (NR2E3, PNR, RNR), found in rod photoreceptor cells (EC50 = 141 nM ß-lactamase assay, 35 nM NCOR assay).1 An interesting tool for targeting age-related macular degeneration. 11a was able to increase p53 activation in uterine cancer tumors suggesting NR2E3 agonism as a new anti-cancer strategy.2 A previous study found that cytotoxicity of 11a was due to G1/S phase cell cycle arrest rather than NR2E3 agonism.3
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