UNC0379, CAS [[1620401-82-2]]

Produktübersicht

• Artikelname: UNC0379, CAS [[1620401-82-2]]
• Artikelnummer: FBM-10-4870
• Hersteller Artikelnummer: 10-4870
• Alternativnummer: FBM-10-4870-5MG,FBM-10-4870-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

SETD8 inhibitor

Produkteigenschaften

• Molekulargewicht: 413.56
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Tan solid
• CAS Nummer: [1620401-82-2]
• Formel: C23H35N5O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: UNC0379 is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50s = 7.3 µM in a radioactive methyl transfer assay and 9.0 µM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.2