UNC0379, CAS [[1620401-82-2]]

Product Overview

• Article Name: UNC0379, CAS [[1620401-82-2]]
• Biozol Catalog Number: FBM-10-4870
• Supplier Catalog Number: 10-4870
• Alternative Catalog Number: FBM-10-4870-5MG, FBM-10-4870-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine

Product Description

SETD8 inhibitor

Product Properties

• Molecular Weight: 413.56
• Purity: 98% by TLC NMR (Conforms)
• Form: Tan solid
• CAS Number: [1620401-82-2]
• Formula: C23H35N5O2

Application Notes

• Application Notes: UNC0379 is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50s = 7.3 µM in a radioactive methyl transfer assay and 9.0 µM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.2