Chemical Name: N-[[2-[(Cyclobutylmethylamino)methyl]-1H-indol-6-yl]methyl]-4-oxopyrido[1,2-a]pyrimidine-2-carboxamide
METTL3 inhibitor
Molekulargewicht:
415.50
Reinheit:
>98% by HPLC NMR (Conforms)
Formulierung:
Pale yellow solid
CAS Nummer:
[2648257-56-9]
Formel:
C24H25N5O2
Anwendungsbeschreibung:
STC-15 is an orally bioavailable inhibitor of the RNA methyltransferase METTL3. Inhibits acute myeloid leukemia growth and induces anti-cancer immunity via activation of double strand RNA sensing machinery and interferon signaling. STC-15 synergizes with radiation therapy and T cell checkpoint blockade and enhances the cytotoxicity of doxorubicin chemotherapy.
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