Chemical Name: (E)-2-Cyano-3-[5-(3-hydroxyphenyl)thiophen-2-yl]prop-2-enamide. Alternate Names: (E)-2-Cyano-3-[5-(3-hydroxyphenyl)thiophen-2-yl]acrylamide
YTHDF2 inhibitor
Molekulargewicht:
270.31
Reinheit:
>98% by TLC NMR (Conforms)
Formulierung:
Yellow solid
CAS Nummer:
[3069691-93-6]
Formel:
C14H10N2O2S
Anwendungsbeschreibung:
DC-Y13-27 is an inhibitor (IC50 = 21.8 µM) of the RNA N6-methyladenosine (m6A) reader YTHDF2.1 It significantly enhanced tumor growth inhibition in MC38 murine models in conjunction with radiotherapy and/or anti-PD-L1 therapy via an increase in the number of CD8+ T cells.
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