Fexaramine, CAS [[574013-66-4]]

Produktübersicht

• Artikelname: Fexaramine, CAS [[574013-66-4]]
• Artikelnummer: FBM-10-4897
• Hersteller Artikelnummer: 10-4897
• Alternativnummer: FBM-10-4897-5MG, FBM-10-4897-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: Methyl (E)-3-[3-[cyclohexanecarbonyl-[[4-[4-(dimethylamino)phenyl]phenyl]methyl]amino]phenyl]prop-2-enoate

Produktbeschreibung

FXR agonist

Produkteigenschaften

• Molekulargewicht: 496.65
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [574013-66-4]
• Formel: C32H36N2O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: Fexaramine is a potent (EC50 = 25 nM) and selective agonist of the nuclear bile acid receptor FXR.1 It significantly enhanced osteoblastic differentiation and suppressed osteoclast differentiation from bone marrow macrophages.2 Fexaramine induces enteric FGF15 and reduces diet-induced weight gain, body-wide inflammation, and hepatic glucose production while enhancing thermogenesis and browning of white adipose tissue.3 It protected mice from ethanol-induced liver injury4 and decreased lipid accumulation via hepatic fatty acid oxidation5.