Fexaramine, CAS [[574013-66-4]]

Product Overview

• Article Name: Fexaramine, CAS [[574013-66-4]]
• Biozol Catalog Number: FBM-10-4897
• Supplier Catalog Number: 10-4897
• Alternative Catalog Number: FBM-10-4897-5MG, FBM-10-4897-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: Methyl (E)-3-[3-[cyclohexanecarbonyl-[[4-[4-(dimethylamino)phenyl]phenyl]methyl]amino]phenyl]prop-2-enoate

Product Description

FXR agonist

Product Properties

• Molecular Weight: 496.65
• Purity: >98% by HPLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [574013-66-4]
• Formula: C32H36N2O3

Application Notes

• Application Notes: Fexaramine is a potent (EC50 = 25 nM) and selective agonist of the nuclear bile acid receptor FXR.1 It significantly enhanced osteoblastic differentiation and suppressed osteoclast differentiation from bone marrow macrophages.2 Fexaramine induces enteric FGF15 and reduces diet-induced weight gain, body-wide inflammation, and hepatic glucose production while enhancing thermogenesis and browning of white adipose tissue.3 It protected mice from ethanol-induced liver injury4 and decreased lipid accumulation via hepatic fatty acid oxidation5.