BMS-1166, CAS [[1818314-88-3]]

Produktübersicht

• Artikelname: BMS-1166, CAS [[1818314-88-3]]
• Artikelnummer: FBM-10-4903
• Hersteller Artikelnummer: 10-4903
• Alternativnummer: FBM-10-4903-1MG, FBM-10-4903-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (2R,4R)-1-[[5-Chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid

Produktbeschreibung

PD-1/PD-L1 inhibitor

Produkteigenschaften

• Molekulargewicht: 641.12
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1818314-88-3]
• Formel: C36H33ClN2O7

Anwendungsbeschreibung

• Anwendungsbeschreibung: BMS-1166 blocks the cell surface interaction of PD-L1 with PD-1 alleviating the inhibitory effect of PD-L1 on T-cell receptor-mediated activation of T-lymphocytes (IC50 = 1.4 nM).1,2 It suppressed growth and invasion of glioma cells3 and induced apoptosis in conjunction with the dual PI3K/mTOR inhibitor BEZ2354. BMS-1166 reversed HEL-mediated T cell suppression in acute myeloid leukemia patients.5 It significantly decreased cell viability and enhanced chemotherapy-induced cytotoxicity in MDF-MB-231 and MCF-7 breast cancer models.6