BMS-1166, CAS [[1818314-88-3]]

Product Overview

• Article Name: BMS-1166, CAS [[1818314-88-3]]
• Biozol Catalog Number: FBM-10-4903
• Supplier Catalog Number: 10-4903
• Alternative Catalog Number: FBM-10-4903-1MG, FBM-10-4903-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2R,4R)-1-[[5-Chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxypyrrolidine-2-carboxylic acid

Product Description

PD-1/PD-L1 inhibitor

Product Properties

• Molecular Weight: 641.12
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1818314-88-3]
• Formula: C36H33ClN2O7

Application Notes

• Application Notes: BMS-1166 blocks the cell surface interaction of PD-L1 with PD-1 alleviating the inhibitory effect of PD-L1 on T-cell receptor-mediated activation of T-lymphocytes (IC50 = 1.4 nM).1,2 It suppressed growth and invasion of glioma cells3 and induced apoptosis in conjunction with the dual PI3K/mTOR inhibitor BEZ2354. BMS-1166 reversed HEL-mediated T cell suppression in acute myeloid leukemia patients.5 It significantly decreased cell viability and enhanced chemotherapy-induced cytotoxicity in MDF-MB-231 and MCF-7 breast cancer models.6