SX-682, CAS [[1648843-04-2]]

Produktübersicht

• Artikelname: SX-682, CAS [[1648843-04-2]]
• Artikelnummer: FBM-10-4925
• Hersteller Artikelnummer: 10-4925
• Alternativnummer: FBM-10-4925-5MG, FBM-10-4925-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: [2-[[5-[(4-Fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid

Produktbeschreibung

CXCR1/2 inhibitor

Produkteigenschaften

• Molekulargewicht: 467.20
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [1648843-04-2]
• Formel: C19H14BF4N3O4S

Anwendungsbeschreibung

• Anwendungsbeschreibung: SX-682 is a novel CXCR1/2 inhibitor (IC50s: CXCR1 = 42 nM, CXCR2 = 20 nM)1. It displayed robust synergistic activity with immune checkpoint blockade against castration resistant prostate cancer.2 It significantly reduced tumor burden in a Ptenfl/fl/Lkb1fl/fl mouse model of lung squamous cell cancer when used in combination with anti-PD1 therapy.3 SX-682 significantly inhibited trafficking of neutrophilic myeloid-derived suppressor cells (PMN-MDSCs) enhancing anti-PD1 immune checkpoint blockade, T cell-based immunotherapy, and NK-cell immunotherapy.4,5