SX-682, CAS [[1648843-04-2]]

Product Overview

• Article Name: SX-682, CAS [[1648843-04-2]]
• Biozol Catalog Number: FBM-10-4925
• Supplier Catalog Number: 10-4925
• Alternative Catalog Number: FBM-10-4925-5MG, FBM-10-4925-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: [2-[[5-[(4-Fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid

Product Description

CXCR1/2 inhibitor

Product Properties

• Molecular Weight: 467.20
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [1648843-04-2]
• Formula: C19H14BF4N3O4S

Application Notes

• Application Notes: SX-682 is a novel CXCR1/2 inhibitor (IC50s: CXCR1 = 42 nM, CXCR2 = 20 nM)1. It displayed robust synergistic activity with immune checkpoint blockade against castration resistant prostate cancer.2 It significantly reduced tumor burden in a Ptenfl/fl/Lkb1fl/fl mouse model of lung squamous cell cancer when used in combination with anti-PD1 therapy.3 SX-682 significantly inhibited trafficking of neutrophilic myeloid-derived suppressor cells (PMN-MDSCs) enhancing anti-PD1 immune checkpoint blockade, T cell-based immunotherapy, and NK-cell immunotherapy.4,5