Telaprevir, CAS [[402957-28-2]]

Produktübersicht

• Artikelname: Telaprevir, CAS [[402957-28-2]]
• Artikelnummer: FBM-10-4929
• Hersteller Artikelnummer: 10-4929
• Alternativnummer: FBM-10-4929-5MG, FBM-10-4929-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (3S,3aS,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide. Alternate Names: VX-950

Produktbeschreibung

Hepatitis C protease inhibitor

Produkteigenschaften

• Molekulargewicht: 679.86
• Reinheit: 98% by HPLC NMR (conforms)
• Formulierung: White solid
• CAS Nummer: [402957-28-2]
• Formel: C36H53N7O6

Anwendungsbeschreibung

• Anwendungsbeschreibung: Hepatitis C NS3/4A protease inhibitor that is in clinical use for genotype 1 infections (IC50 = 354 nM genotype 1b replicon cells, IC50 = 280 nM human fetal hepatocytes infected with genotype 1a HCV-positive patient sera).1-3 It has been shown to inhibit SARS-CoV2 proteases MPro (IC50 = 15 µM)4 and 3CLPro (IC50 = 56 µM)5. Telaprevir is also an allosteric inhibitor of DnaK, the bacterial homolog of Hsp70. It enhanced the efficacy of aminoglycoside antibiotics and reduced resistance to the tuberculosis drug rifampin.6