Telaprevir, CAS [[402957-28-2]]

Product Overview

• Article Name: Telaprevir, CAS [[402957-28-2]]
• Biozol Catalog Number: FBM-10-4929
• Supplier Catalog Number: 10-4929
• Alternative Catalog Number: FBM-10-4929-5MG, FBM-10-4929-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (3S,3aS,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide. Alternate Names: VX-950

Product Description

Hepatitis C protease inhibitor

Product Properties

• Molecular Weight: 679.86
• Purity: 98% by HPLC NMR (conforms)
• Form: White solid
• CAS Number: [402957-28-2]
• Formula: C36H53N7O6

Application Notes

• Application Notes: Hepatitis C NS3/4A protease inhibitor that is in clinical use for genotype 1 infections (IC50 = 354 nM genotype 1b replicon cells, IC50 = 280 nM human fetal hepatocytes infected with genotype 1a HCV-positive patient sera).1-3 It has been shown to inhibit SARS-CoV2 proteases MPro (IC50 = 15 µM)4 and 3CLPro (IC50 = 56 µM)5. Telaprevir is also an allosteric inhibitor of DnaK, the bacterial homolog of Hsp70. It enhanced the efficacy of aminoglycoside antibiotics and reduced resistance to the tuberculosis drug rifampin.6