MS102

Produktübersicht

• Artikelname: MS102
• Artikelnummer: FBM-10-4937
• Hersteller Artikelnummer: 10-4937
• Alternativnummer: FBM-10-4937-5MG, FBM-10-4937-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-(4-(4-Bromophenyl)thiazol-2-yl)-2-((4-methylphenyl)sulfonamido)-5-(trifluoromethyl)benzamide

Produktbeschreibung

USP2 inhibitor

Produkteigenschaften

• Molekulargewicht: 596.44
• Reinheit: >98% by HPLC NMR (conforms)
• Formulierung: White solid
• Formel: C24H17BrF3N3O3S2

Anwendungsbeschreibung

• Anwendungsbeschreibung: MS102 is an orally bioavailable derivative (IC50 = 5.46 µM) of the USP2 inhibitor ML364.1 It displayed improved USP2 inhibition efficacy and improved antiviral activity (SARS-CoV-2 HepG2 and Calu-3 cells) compared to ML364. Antiviral activity of MS102 is via inhibition of the deubquitinase activity of USP2 on ACE2 resulting in reduction of ACE2 levels. MS102 significantly reduces V-domain Ig suppressor of T cell activation (VISTA) protein abundance in syngeneic mouse tumor models to enhance T cell response and synergizes with anti-PD-1 immunotherapy.2