Chemical Name: N-(4-(4-Bromophenyl)thiazol-2-yl)-2-((4-methylphenyl)sulfonamido)-5-(trifluoromethyl)benzamide
USP2 inhibitor
Molecular Weight:
596.44
Purity:
>98% by HPLC NMR (conforms)
Form:
White solid
Formula:
C24H17BrF3N3O3S2
Application Notes:
MS102 is an orally bioavailable derivative (IC50 = 5.46 µM) of the USP2 inhibitor ML364.1 It displayed improved USP2 inhibition efficacy and improved antiviral activity (SARS-CoV-2 HepG2 and Calu-3 cells) compared to ML364. Antiviral activity of MS102 is via inhibition of the deubquitinase activity of USP2 on ACE2 resulting in reduction of ACE2 levels. MS102 significantly reduces V-domain Ig suppressor of T cell activation (VISTA) protein abundance in syngeneic mouse tumor models to enhance T cell response and synergizes with anti-PD-1 immunotherapy.2
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