ML792, CAS [[1644342-14-2]]

Produktübersicht

• Artikelname: ML792, CAS [[1644342-14-2]]
• Artikelnummer: FBM-10-4985
• Hersteller Artikelnummer: 10-4985
• Alternativnummer: FBM-10-4985-5MG,FBM-10-4985-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

SUMO-activating enzyme (SAE) inhibitor

Produkteigenschaften

• Molekulargewicht: 551.42
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1644342-14-2]
• Formel: C21H23BrN6O5S

Anwendungsbeschreibung

• Anwendungsbeschreibung: ML792 is a potent (IC50s = 3 nM SUMO1, 11 nM SUMO2) and selective( IC50 = 32 µM for NEDD8-activating enzyme (NAE)) mechanism-based inhibitor of SUMO-activating enzyme (SAE).1 Treatment of multiple cancer cell lines led to failure of mitotic progression and induction of endoreduplication with MYC-amplified cell lines showing higher sensitivity. ML792 inhibited B-cell growth and promoted cell death in Epstein-Barr virus (EBV)-positive B cells and nasopharyngeal carcinoma cells. It also modulated Latent Membrane Protein-1-induced cell migration and cell adhesion suggesting therapeutic potential in treating EBV-associated malignancies.2