ML792, CAS [[1644342-14-2]]

Product Overview

• Article Name: ML792, CAS [[1644342-14-2]]
• Biozol Catalog Number: FBM-10-4985
• Supplier Catalog Number: 10-4985
• Alternative Catalog Number: FBM-10-4985-5MG, FBM-10-4985-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: [(1R,2S,4R)-4-[[5-[1-[(3-Bromophenyl)methyl]pyrazole-3-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate

Product Description

SUMO-activating enzyme (SAE) inhibitor

Product Properties

• Molecular Weight: 551.42
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1644342-14-2]
• Formula: C21H23BrN6O5S

Application Notes

• Application Notes: ML792 is a potent (IC50s = 3 nM SUMO1, 11 nM SUMO2) and selective( IC50 = 32 µM for NEDD8-activating enzyme (NAE)) mechanism-based inhibitor of SUMO-activating enzyme (SAE).1 Treatment of multiple cancer cell lines led to failure of mitotic progression and induction of endoreduplication with MYC-amplified cell lines showing higher sensitivity. ML792 inhibited B-cell growth and promoted cell death in Epstein-Barr virus (EBV)-positive B cells and nasopharyngeal carcinoma cells. It also modulated Latent Membrane Protein-1-induced cell migration and cell adhesion suggesting therapeutic potential in treating EBV-associated malignancies.2