STING Degrader 1, CAS [[2762552-74-7]]

Produktübersicht

• Artikelname: STING Degrader 1, CAS [[2762552-74-7]]
• Artikelnummer: FBM-10-5001
• Hersteller Artikelnummer: 10-5001
• Alternativnummer: FBM-10-5001-1MG, FBM-10-5001-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (E)-N-[6-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexyl]-N-[4-[(5-nitrofuran-2-carbonyl)amino]phenyl]but-2-enediamide. Alternate Names: SP23

Produktbeschreibung

STING PROTAC degrader

Produkteigenschaften

• Molekulargewicht: 699.68
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Yellow to beige solid
• CAS Nummer: [2762552-74-7]
• Formel: C34H33N7O10

Anwendungsbeschreibung

• Anwendungsbeschreibung: STING degrader 1 (2762552-74-7) is a CRBN-based PROTAC degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the proteasomal degradation of the Stimulator of Interferon Genes (STING). This degrader was designed by coupling C-170, a small molecule STING inhibitor with pomalidomide via a C-6 linker. It selectively degrades STING with a DC50=3.2 µM.1 It displays antiinflammatory activity in a cisplatin-induced acute kidney injury mouse model.1