STING Degrader 1, CAS [[2762552-74-7]]

Product Overview

• Article Name: STING Degrader 1, CAS [[2762552-74-7]]
• Biozol Catalog Number: FBM-10-5001
• Supplier Catalog Number: 10-5001
• Alternative Catalog Number: FBM-10-5001-1MG, FBM-10-5001-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (E)-N-[6-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexyl]-N-[4-[(5-nitrofuran-2-carbonyl)amino]phenyl]but-2-enediamide. Alternate Names: SP23

Product Description

STING PROTAC degrader

Product Properties

• Molecular Weight: 699.68
• Purity: >98% by HPLC NMR (Conforms)
• Form: Yellow to beige solid
• CAS Number: [2762552-74-7]
• Formula: C34H33N7O10

Application Notes

• Application Notes: STING degrader 1 (2762552-74-7) is a CRBN-based PROTAC degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the proteasomal degradation of the Stimulator of Interferon Genes (STING). This degrader was designed by coupling C-170, a small molecule STING inhibitor with pomalidomide via a C-6 linker. It selectively degrades STING with a DC50=3.2 µM.1 It displays antiinflammatory activity in a cisplatin-induced acute kidney injury mouse model.1