Phenylhexyl isothiocyanate, CAS [[133920-06-6]]

Produktübersicht

• Artikelname: Phenylhexyl isothiocyanate, CAS [[133920-06-6]]
• Artikelnummer: FBM-10-5258
• Hersteller Artikelnummer: 10-5258
• Alternativnummer: FBM-10-5258-5MG, FBM-10-5258-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 6-Isothiocyanatohexylbenzene. Alternate Names: PHITC, PHI

Produktbeschreibung

Chemopreventive, HDAC inhibitor, p53 reactivator

Produkteigenschaften

• Molekulargewicht: 219.35
• Reinheit: >98% by TLC NMR (Conforms)
• Formulierung: Colorless to pale yellow liquid
• CAS Nummer: [133920-06-6]
• Formel: C13H17NS

Anwendungsbeschreibung

• Anwendungsbeschreibung: Isothiocyanate constituents of cruciferous vegetables are potent chemopreventive agents for carcinogen-induced cancers in rodents.1 PHITC was the most potent in a series of synthetic arylalkyl isothiocyanates at inhibition of tumorigenicity by NNK, a tobacco-derived nitrosamine, in a mouse model.2 It was also found to induce apoptosis and inhibit leukemia cell growth in vivo3 and was shown to have dual function as a histone deacetylase inhibitor and hypomethylating agent4. PHITC was also shown to restore the activity of mutant p53 and reactivate the p53 pathway in human myeloid leukemia M2 cells.5