Chemical Name: 6-Isothiocyanatohexylbenzene. Alternate Names: PHITC, PHI
Chemopreventive, HDAC inhibitor, p53 reactivator
Molecular Weight:
219.35
Purity:
>98% by TLC NMR (Conforms)
Form:
Colorless to pale yellow liquid
CAS Number:
[133920-06-6]
Formula:
C13H17NS
Application Notes:
Isothiocyanate constituents of cruciferous vegetables are potent chemopreventive agents for carcinogen-induced cancers in rodents.1 PHITC was the most potent in a series of synthetic arylalkyl isothiocyanates at inhibition of tumorigenicity by NNK, a tobacco-derived nitrosamine, in a mouse model.2 It was also found to induce apoptosis and inhibit leukemia cell growth in vivo3 and was shown to have dual function as a histone deacetylase inhibitor and hypomethylating agent4. PHITC was also shown to restore the activity of mutant p53 and reactivate the p53 pathway in human myeloid leukemia M2 cells.5
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