ABT-869, CAS [[796967-16-3]]

Produktübersicht

• Artikelname: ABT-869, CAS [[796967-16-3]]
• Artikelnummer: FBM-10-5268
• Hersteller Artikelnummer: 10-5268
• Alternativnummer: FBM-10-5268-5MG,FBM-10-5268-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Linifanib

Produktbeschreibung

Dual VEGFR and PDGFR kinase inhibitor

Produkteigenschaften

• Molekulargewicht: 375.41
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [796967-16-3]
• Formel: C21H18FN5O

Anwendungsbeschreibung

• Anwendungsbeschreibung: ABT-869 (796967-16-3) ia a structurally novel, potent inhibitor of receptor tyrosine kinases inhibiting VEGFR and PDGFR and related kinases with IC50s= 3, 4, 4, 66, 3 and 14 nM for VEGFR1, VEGFR2, FLT3, PDGFRbeta, CSF-1R and KIT respectively.1,2 Protects cells from necroptosis and rescues SIRS mice from TNF-alpha-induced shock and death.3 Exerts anti-obesity effects by promoting adipocyte browning.4 Inhibits angiogenesis.5