ABT-869, CAS [[796967-16-3]]

Product Overview

• Article Name: ABT-869, CAS [[796967-16-3]]
• Biozol Catalog Number: FBM-10-5268
• Supplier Catalog Number: 10-5268
• Alternative Catalog Number: FBM-10-5268-5MG, FBM-10-5268-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-(4-(3-Amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea. Alternate Names: Linifanib

Product Description

Dual VEGFR and PDGFR kinase inhibitor

Product Properties

• Molecular Weight: 375.41
• Purity: >98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [796967-16-3]
• Formula: C21H18FN5O

Application Notes

• Application Notes: ABT-869 (796967-16-3) ia a structurally novel, potent inhibitor of receptor tyrosine kinases inhibiting VEGFR and PDGFR and related kinases with IC50s= 3, 4, 4, 66, 3 and 14 nM for VEGFR1, VEGFR2, FLT3, PDGFRbeta, CSF-1R and KIT respectively.1,2 Protects cells from necroptosis and rescues SIRS mice from TNF-alpha-induced shock and death.3 Exerts anti-obesity effects by promoting adipocyte browning.4 Inhibits angiogenesis.5