MLS-544460, CAS [[352336-36-8]]

Produktübersicht

• Artikelname: MLS-544460, CAS [[352336-36-8]]
• Artikelnummer: FBM-10-5332
• Hersteller Artikelnummer: 10-5332
• Alternativnummer: FBM-10-5332-5MG, FBM-10-5332-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-Fluoro-N-((E)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino)benzamide. Alternate Names: MLS000544460

Produktbeschreibung

Eya2 phosphatase inhibitor

Produkteigenschaften

• Molekulargewicht: 341.36
• Reinheit: >98% by TLC NMR (Conforms)
• Formulierung: Cream/off-white solid
• CAS Nummer: [352336-36-8]
• Formel: C17H12FN3O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: MLS-544460 is an allosteric inhibitor of the Eya2 tyrosine phosphatase (IC50=4.1 uM)1-2 which is ineffective against other tyrosine phosphatases including Eya3 and PTP1B. Treatment of patient-derived glioma stem cells induced loss of bipolar spindle formation along with G2/M cell cycle arrest. GSC proliferation was inhibited at concentrations 4 to 10-fold lower than normal brain cells.3 Treatment of Axolotls following amputation impairs limb regeneration indicating a role for Eya2 in vertebrate regeneration.4