MLS-544460, CAS [[352336-36-8]]

Product Overview

• Article Name: MLS-544460, CAS [[352336-36-8]]
• Biozol Catalog Number: FBM-10-5332
• Supplier Catalog Number: 10-5332
• Alternative Catalog Number: FBM-10-5332-5MG,FBM-10-5332-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: MLS000544460

Product Description

Eya2 phosphatase inhibitor

Product Properties

• Molecular Weight: 341.36
• Purity: >98% by TLC NMR (Conforms)
• Form: Cream/off-white solid
• CAS Number: [352336-36-8]
• Formula: C17H12FN3O2S

Application Notes

• Application Notes: MLS-544460 is an allosteric inhibitor of the Eya2 tyrosine phosphatase (IC50=4.1 uM)1-2 which is ineffective against other tyrosine phosphatases including Eya3 and PTP1B. Treatment of patient-derived glioma stem cells induced loss of bipolar spindle formation along with G2/M cell cycle arrest. GSC proliferation was inhibited at concentrations 4 to 10-fold lower than normal brain cells.3 Treatment of Axolotls following amputation impairs limb regeneration indicating a role for Eya2 in vertebrate regeneration.4