AS1842856 is a potent and selective FOXO1 inhibitor, IC50s=33 nM and >1 mM for FOXO3a and 4.1 Oral administration to diabetic db/db mice leads to a reduction of fasting plasma glucose levels.1 Suppresses autophagy, FSP27 expression and adipocyte differentiation.2 AS1842856 is a highly useful tool for probing the involvement of FOXO1 in cellular processes.3-5
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