Locostatin, CAS [[133812-16-5]]

Produktübersicht

• Artikelname: Locostatin, CAS [[133812-16-5]]
• Artikelnummer: FBM-10-5381
• Hersteller Artikelnummer: 10-5381
• Alternativnummer: FBM-10-5381-5MG, FBM-10-5381-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone. Alternate Names: UIC-1005

Produktbeschreibung

RKIP/Raf-1 kinase disruptor

Produkteigenschaften

• Molekulargewicht: 245.28
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [133812-16-5]
• Formel: C14H15O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: Inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3 Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5