Locostatin, CAS [[133812-16-5]]

Product Overview

• Article Name: Locostatin, CAS [[133812-16-5]]
• Biozol Catalog Number: FBM-10-5381
• Supplier Catalog Number: 10-5381
• Alternative Catalog Number: FBM-10-5381-5MG, FBM-10-5381-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone. Alternate Names: UIC-1005

Product Description

RKIP/Raf-1 kinase disruptor

Product Properties

• Molecular Weight: 245.28
• Purity: 98% by TLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [133812-16-5]
• Formula: C14H15O3

Application Notes

• Application Notes: Inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3 Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5