Chemical Name: 2-[[(benzoylamino)thioxomethyl]amino]-4,7-dihydro-5,5-dimethyl-5H-thieno[2,3-c]pyran-3-carboxylic acid. Alternate Names: ML282
Rab7 GTPase inhibitor
Molekulargewicht:
390.48
Reinheit:
98% by TLC NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[314042-01-8]
Formel:
C18H18N2O4S2
Anwendungsbeschreibung:
A specific competitive inhibitor of nucleotide binding to Rab7, an endosome-localized small GTPase.1 It interferes with the Rab7-RILP interaction, locking the GTPase in an inactive conformation.2 Impairs B cell class switching and plasma cell survival dampening, the pathogenic autoantibody response in lupus.3 Inhibits the Arf-like small GTPase Arl8b, blocking cellular egress of b-coronaviruses (SARS-CoV-2) which utilize a lysosomal exocytosis pathway.4
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