PI-103, CAS [[371935-74-9]]

Produktübersicht

• Artikelname: PI-103, CAS [[371935-74-9]]
• Artikelnummer: FBM-10-5406
• Hersteller Artikelnummer: 10-5406
• Alternativnummer: FBM-10-5406-5MG, FBM-10-5406-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-[4-(4-morpholinyl)pyrido[3,2:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol

Produktbeschreibung

PI3K, mTOR and DNA-PK inhibitor

Produkteigenschaften

• Molekulargewicht: 348.36
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [371935-74-9]
• Formel: C19H16N4O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: A potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48, 20, 83 and 2 nM for p110alpha, p110ß, p110gamma, p110delta, mTORC1, mTORC2 and DNA-PK respectively.1,2 Synergizes with arsenic disulfide to eradicate AML stem cells by induction of differentiation.3 Inhibits the growth of gefitinib-resistant non-small cell lung cancer cell lines.4 Induces autophagy in drug-resistant glioma.5 Protects against a-synuclein-induced toxicity in human neurons by induction of macroautophagy.6