PI-103, CAS [[371935-74-9]]

Product Overview

• Article Name: PI-103, CAS [[371935-74-9]]
• Biozol Catalog Number: FBM-10-5406
• Supplier Catalog Number: 10-5406
• Alternative Catalog Number: FBM-10-5406-5MG, FBM-10-5406-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-[4-(4-morpholinyl)pyrido[3,2:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol

Product Description

PI3K, mTOR and DNA-PK inhibitor

Product Properties

• Molecular Weight: 348.36
• Purity: 98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [371935-74-9]
• Formula: C19H16N4O3

Application Notes

• Application Notes: A potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48, 20, 83 and 2 nM for p110alpha, p110ß, p110gamma, p110delta, mTORC1, mTORC2 and DNA-PK respectively.1,2 Synergizes with arsenic disulfide to eradicate AML stem cells by induction of differentiation.3 Inhibits the growth of gefitinib-resistant non-small cell lung cancer cell lines.4 Induces autophagy in drug-resistant glioma.5 Protects against a-synuclein-induced toxicity in human neurons by induction of macroautophagy.6