AR7, CAS [[80306-38-3]]

Produktübersicht

• Artikelname: AR7, CAS [[80306-38-3]]
• Artikelnummer: FBM-10-5515
• Hersteller Artikelnummer: 10-5515
• Alternativnummer: FBM-10-5515-5MG, FBM-10-5515-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine

Produktbeschreibung

Activates chaperone mediated autophagy

Produkteigenschaften

• Molekulargewicht: 257.72
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Pale pink solid
• CAS Nummer: [80306-38-3]
• Formel: C15H12ClNO

Anwendungsbeschreibung

• Anwendungsbeschreibung: Atypical retinoid which acts as an RARalpha antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinsons disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4