AR7, CAS [[80306-38-3]]

Product Overview

• Article Name: AR7, CAS [[80306-38-3]]
• Biozol Catalog Number: FBM-10-5515
• Supplier Catalog Number: 10-5515
• Alternative Catalog Number: FBM-10-5515-5MG, FBM-10-5515-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine

Product Description

Activates chaperone mediated autophagy

Product Properties

• Molecular Weight: 257.72
• Purity: 98% by TLC NMR (Conforms)
• Form: Pale pink solid
• CAS Number: [80306-38-3]
• Formula: C15H12ClNO

Application Notes

• Application Notes: Atypical retinoid which acts as an RARalpha antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinsons disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4