Novel small molecule inducer of angiogenesis which has been shown to be useful in tissue engineering applications.1 In a sustained release model, PNF1 promoted ingrowth and expansion of microvascular networks surrounding biomaterial implants.2 Its mechanism of action includes induction of TNF-alpha followed by TGF-beta signaling and subsequent modulation of MMP14 (MT1-MMP) in human microvascular endothelial cells.3,4
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