Chemical Name: 2-(2-Oxocyclopentyl)isoindoline-1,3-dione. Alternate Names: SC-3-149
Angiogenesis inducer
Molecular Weight:
229.24
Purity:
98% by TLC NMR (Conforms)
Form:
Off-white solid
CAS Number:
[10442-95-2]
Formula:
C13H11NO3
Application Notes:
Novel small molecule inducer of angiogenesis which has been shown to be useful in tissue engineering applications.1 In a sustained release model, PNF1 promoted ingrowth and expansion of microvascular networks surrounding biomaterial implants.2 Its mechanism of action includes induction of TNF-alpha followed by TGF-beta signaling and subsequent modulation of MMP14 (MT1-MMP) in human microvascular endothelial cells.3,4
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