KNK437, CAS [[218924-25-5]]

Produktübersicht

• Artikelname: KNK437, CAS [[218924-25-5]]
• Artikelnummer: FBM-10-5561
• Hersteller Artikelnummer: 10-5561
• Alternativnummer: FBM-10-5561-5MG, FBM-10-5561-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde

Produktbeschreibung

Inhibits HSP70 expression

Produkteigenschaften

• Molekulargewicht: 245.23
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [218924-25-5]
• Formel: C13H11NO4

Anwendungsbeschreibung

• Anwendungsbeschreibung: Inhibits constitutive and inducible HSP70 expression in non-stressed1 and heat-stressed2 cancer cells. Blocks the geldanamycin-induced induction of HSP70 and inhibition of TGFß signaling.3 Inhibits leukocyte integrin alpha4ß7-mediated adhesion of T cells to mucosal addressin cell adhesion molecule 1 (MAdCAM-1) suggesting that HSP70 is essential for ß7 integrin signalling.4 Suppresses morphine analgesic tolerance in a rodent model (100 mg/Kg).5