KNK437, CAS [[218924-25-5]]

Product Overview

• Article Name: KNK437, CAS [[218924-25-5]]
• Biozol Catalog Number: FBM-10-5561
• Supplier Catalog Number: 10-5561
• Alternative Catalog Number: FBM-10-5561-5MG, FBM-10-5561-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde

Product Description

Inhibits HSP70 expression

Product Properties

• Molecular Weight: 245.23
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [218924-25-5]
• Formula: C13H11NO4

Application Notes

• Application Notes: Inhibits constitutive and inducible HSP70 expression in non-stressed1 and heat-stressed2 cancer cells. Blocks the geldanamycin-induced induction of HSP70 and inhibition of TGFß signaling.3 Inhibits leukocyte integrin alpha4ß7-mediated adhesion of T cells to mucosal addressin cell adhesion molecule 1 (MAdCAM-1) suggesting that HSP70 is essential for ß7 integrin signalling.4 Suppresses morphine analgesic tolerance in a rodent model (100 mg/Kg).5