L6H21, CAS [[24533-47-9]]

Produktübersicht

• Artikelname: L6H21, CAS [[24533-47-9]]
• Artikelnummer: FBM-10-5574
• Hersteller Artikelnummer: 10-5574
• Alternativnummer: FBM-10-5574-5MG, FBM-10-5574-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (2E)-3-(2,3-Dimethoxyphenyl)-1-(4-methoxyphenyl)-2-propen-1-one, (E)-2,3-dimethoxy-4'-methoxychalcone

Produktbeschreibung

MDL/TLR4 interaction inhibitor

Produkteigenschaften

• Molekulargewicht: 298.34
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [24533-47-9]
• Formel: C18H18O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: L6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 µM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated cells, inhibiting TNFalpha and IL-6 production.1 Attenuates disease progression in a high-fat diet (HFD) induced NASH mouse model.2 Inhibits obesity-induced cardiomyopathy and fibrosis.3 Reduces ethanol plus LPS-induced liver injury via inhibition of NLRP3 inflammasome activation.4 Provides cardioprotective effects5 and protects against cognitive impairment and brain pathologies in HFD prediabetic rats6. Cell permeable. Active in vivo.