L6H21, CAS [[24533-47-9]]

Product Overview

• Article Name: L6H21, CAS [[24533-47-9]]
• Biozol Catalog Number: FBM-10-5574
• Supplier Catalog Number: 10-5574
• Alternative Catalog Number: FBM-10-5574-5MG, FBM-10-5574-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2E)-3-(2,3-Dimethoxyphenyl)-1-(4-methoxyphenyl)-2-propen-1-one, (E)-2,3-dimethoxy-4'-methoxychalcone

Product Description

MDL/TLR4 interaction inhibitor

Product Properties

• Molecular Weight: 298.34
• Purity: 98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [24533-47-9]
• Formula: C18H18O4

Application Notes

• Application Notes: L6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 µM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated cells, inhibiting TNFalpha and IL-6 production.1 Attenuates disease progression in a high-fat diet (HFD) induced NASH mouse model.2 Inhibits obesity-induced cardiomyopathy and fibrosis.3 Reduces ethanol plus LPS-induced liver injury via inhibition of NLRP3 inflammasome activation.4 Provides cardioprotective effects5 and protects against cognitive impairment and brain pathologies in HFD prediabetic rats6. Cell permeable. Active in vivo.