VE-821, CAS [[1232410-49-9]]

Produktübersicht

• Artikelname: VE-821, CAS [[1232410-49-9]]
• Artikelnummer: FBM-10-5589
• Hersteller Artikelnummer: 10-5589
• Alternativnummer: FBM-10-5589-5MG,FBM-10-5589-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

ATR inhibitor

Produkteigenschaften

• Molekulargewicht: 368.41
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Beige solid
• CAS Nummer: [1232410-49-9]
• Formel: C18H16N4O3S

Anwendungsbeschreibung

• Anwendungsbeschreibung: VE-821 is a potent and selective ATP-competitive ATR (Ataxia-telangiectasia and Rad3-related protein) inhibitor, Ki=13 nM.1 Increases the sensitivity of pancreatic2 and ovarian3 cancer cells to radiation and chemotherapy. Increased replication stress induced by PARP inhibitors or chemotherapeutic agents increases sensitivity to VE-821 in neuroblastoma cells.4 Enhances the cytotoxicity of DNA damaging agents.5