VE-821, CAS [[1232410-49-9]]

Product Overview

• Article Name: VE-821, CAS [[1232410-49-9]]
• Biozol Catalog Number: FBM-10-5589
• Supplier Catalog Number: 10-5589
• Alternative Catalog Number: FBM-10-5589-5MG, FBM-10-5589-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide

Product Description

ATR inhibitor

Product Properties

• Molecular Weight: 368.41
• Purity: 98% by HPLC NMR (Conforms)
• Form: Beige solid
• CAS Number: [1232410-49-9]
• Formula: C18H16N4O3S

Application Notes

• Application Notes: VE-821 is a potent and selective ATP-competitive ATR (Ataxia-telangiectasia and Rad3-related protein) inhibitor, Ki=13 nM.1 Increases the sensitivity of pancreatic2 and ovarian3 cancer cells to radiation and chemotherapy. Increased replication stress induced by PARP inhibitors or chemotherapeutic agents increases sensitivity to VE-821 in neuroblastoma cells.4 Enhances the cytotoxicity of DNA damaging agents.5