10074-G5, CAS [[413611-93-5]]

Produktübersicht

• Artikelname: 10074-G5, CAS [[413611-93-5]]
• Artikelnummer: FBM-10-5627
• Hersteller Artikelnummer: 10-5627
• Alternativnummer: FBM-10-5627-5MG, FBM-10-5627-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 7-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine

Produktbeschreibung

c-Myc inhibitor

Produkteigenschaften

• Molekulargewicht: 332.32
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Orange solid
• CAS Nummer: [413611-93-5]
• Formel: C18H12N4O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: Inhibits c-Myc by disrupting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity.1 10074-G5 binds to the c-Myc bHLHZip domain with Kd=2.8 mM.1 It was cytotoxic in C-Myc-overexpressing cell lines (IC50s = 13 to 15 mM) but was not active in vivo due to rapid metabolism.2 10074-G5 is a useful tool to probe for involvement of c-Myc involvement in cellular processes.3,4 Binds to and sequesters the intrinsically disordered amyloid-beta (Abeta) in its monomeric soluble state and rescues a C. elegans model of Abeta-associated toxicity.5